Embryology

Research on MEIS1 (in mouse only) Description This is a research paper that we are required to do for a university class called Embryology it’s worth a lot. So please read the instructions carefully and if you have any questions email me. First, the gene we are going to work on is MEIS1 (in mouse ONLY). You have a template that I will attach and you will need to fill it with all the information’s you collected about the gene. Download or scan images (150 dpi minimum) of knockout phenotypes or expression patterns for incorporation into your page with short descriptive legends. USE YOUR OWN WORDS PLEASE AND CITE YOUR REFERENCES - many of the posted pages do not, and were penalized, so do not be misled. Do not cut and paste text from the web, and do not paraphrase. I'd prefer that you do not employ quotes either - I want to read YOUR summary/synthesis in YOUR own words. Don’t forget to provide a References Cited section and to annotate the origin of the images. Include links to other pertinent sites, and make sure that these sites are specific, not generic. It is helpful to provide a few words of description for each link Check the list of pages already present in the dictionary (on the 55-355 website). You can also peek at an example (go to the page Arx2 in Xenopus which I have written as an example that would hit a mid to high B grade) to get an idea for how much/little is required. Note that at the time of writing this sample page, neither the genomic structure of the gene, nor the number of mRNA isoforms was known. This information would normally be a part of mammalian, fly, and fish gene pages. I have also attached some papers that I thought were good when I was doing some research about this gene and I thought you could use them and add more to help you. NOTE: For genes, it is helpful to Google "Genbank" and "OMIM" (Online Mendelian Inheritance in Man) which are resources that are both kept up to date and can lead to more links to articles. From Genbank you can access other links such as Unigene that compare your gene of interest across species. Another useful site is E!Ensembl at http://www.ensembl.org . This site lets you looks at intron/exon structure, mRNA isoforms, and chromosomal location. For categorizing Homeobox genes check out: http://homeodb.zoo.ox.ac.uk